CopiOs® Cancellous Bonvine Particulates Xenograft

Xenogenic Bone Grafts

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CopiOs® Cancellous Bonvine Particulates Xenograft

CopiOs Xenograft does not undergo thermal treatment during processing, for this reason CopiOs Xenograft will be remodeled into newly formed vital bone after a period of time.^{1, 2}

CopiOs® Cancellous Xenograft Clinical Advantages

Retains osteoconductive properties due to the preservation of the original bovine bone matrix collagen and mineral composition, trabecular pattern and original porosity³
Biocompatible and well-tolerated as shown in animal and human studies^2,4,5,6
Ability to remodel into vital bone^2,6,7
Proven performance in large and small bone defects^2,5,8

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Puros Allograft Block Unique Tutoplast Process

In 1969 the Tutoplast Tissue Sterilization Process was developed to sterilize and preserve tissue for implantation. More than 11 million implants have been sterilized through the Tutoplast Process with zero confirmed incidence of implant-associated infection.¹⁷

The Benefits of the Multi-Step Tutoplast Process

For allograft bone grafts, the process preserves the valuable bone mineral, collagen matrix, and tissue integrity ¹⁸ while inactivating pathogens and gently removing unwanted materials, such as cells, antigens, and viruses ¹⁷ – resulting in predictable, reliable, sterile, and safe tissue.¹⁷

A labeled, illustrated diagram showing the five stages of the proprietary Tutoplast® Process used to sterilize Puros® allografts: 1) Alkaline Treatment, 2) Osmotic Treatment, 3) Oxidative Treatment, 4) Solvent Treatment, and 5) Irradiation. Each stage is depicted with a visual cross-section of tissue undergoing the respective sterilization step. The image highlights the science-backed, multi-phase purification process behind ZimVie's trusted tissue solutions.

*Images depict dermal processing

Clinically successful in procedures for:

Ability to remodel into vital bone^2,6,7
Regeneration of periodontal bone defects^9,10
Grafting procedures around immediate placed implants^8,9,11
Alveolar ridge augmentation^5,9,12

CopiOs Cancellous Particulate Xenograft Resources

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Additional Information

Product clearance and availability may be limited to certain countries/regions. Please contact your local sales representative or customer service team.

Instructions of Use

CopiOs Pericardium and CopiOs Cancellous are medical devices class III (MDD).

Unless otherwise indicated, as referenced herein, all trademarks and intellectual property rights are the property of ZimVie Inc. or an affiliate; and all products are manufactured by one or more of the dental subsidiaries of ZimVie Inc. (Biomet 3i, LLC, Zimmer Dental, Inc., etc.) and marketed and distributed by ZimVie and its authorized marketing partners. Tutoplast is a registered trademark of Tutogen Medical GmbH. Safescraper is a trademark of C.G.M. S.P.A. Accura products are manufacturd by ResDevMed Lda. Portugal. Biotivity Hyaluronic Acid is manufactured by Italmed srl. BioMend, BioMend Extend, CopiOs, CopiOs Extend, OsseoGuard, OsseoGuard Flex, RegenerOss Resorbable Xenograft and Socket Repair Membranes are manufactured by Collagen Matrix, Inc. Collagen Matrix is not a subsidiary of ZimVie. IngeniOs products are manufactured by Curasan AG. OsseoGuard PTFE products are manufactured by Osteogenics Biomedical, Inc. Safescraper and Micross are manufactured by META Technologies S.r.L. Puros products are manufactured by Tutogen Medical GmbH. CopiOs Xenograft and CopiOs Pericardium are manufactured by Tutogen Medical GmbH. Screw Fixation Kits are manufactured by Medicon e.G. Endobon is manufactured by Biomet France, Sarl. For additional product information, please refer to the individual product labeling or instructions for use. Product clearance and availability may be limited to certain countries/regions. This material is intended for clinicians only and does not comprise medical advice or recommendations. Distribution to any other recipient is prohibited. This material may not be copied or reprinted without the express written consent of ZimVie Inc. and is not for distribution in France.

CopiOs® Cancellous Bonvine Particulates Xenograft

Xenogenic Bone Grafts